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Coronary artery disease is known as a serious plague because of its regularity in different bits of the world. The signs of coronary artery issue handle a wide range from the mind boggling minor coronary atherosclerosis without angina or ischaemia to sudden passing METHODSThe present study was cross sectional, observational study carried out at tertiary care center. This study was conducted during the period from January 2016 to June 2017. All Type two Diabetes Mellitus 100 patients attending Department of Medicine included in the study. RESULTSMajority of study subjects were in age 51 - 60 years (46 %) having DM (Diabetes Mellitus) since 5 - 10 years (46 %). A lot of patients overweight (40 %), dyslipidaemia (22 %). It mean fasting and post prandial glucose among patients was 164 ± 15.18 mg / dL and 189.4 ± 23.29 mg / dL exclusively. The mean LDL, HDL, VLDL, complete cholesterol and greasy oils levels among patients was 118.14 ± 24.2 mg / dL, 42.60 ± 5.12 mg / dL, 35.68 ± 7.09 mg / dL, 204.96 ± 28.76 mg / dL, 166.17 ± 31.92 mg / dL independently. The regularity was 27 %. The prevalence of MI among DM patients was major in age pack 51 - 60 years (13 %). The ECG changes in calm MI among DM patients showed that a lot of calm MI patients had ST dejection and adjusted T wave inversion (77.77). CONCLUSIONSStandard checking ECG is be commonly useful and unobtrusive gadget in myocardial ischaemia area n asymptomatic diabetic patients
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Resumen Introducción: La enfermedad cardiovascular es la causa principal de muerte en pacientes con diabetes mellitus. La prevalencia de cardiopatía isquémica asintomática es más alta en pacientes diabéticos que en no diabéticos y se asocia a peor pronóstico. Objetivo: Identificar la prevalencia de cardiopatía isquémica asintomática en pacientes con diabetes mellitus tipo 2 en un hospital de tercer nivel de atención de Guatemala y analizar la posible asociación de dicha enfermedad con características epidemiológicas, clínicas y metabólicas. Métodos: Estudio de corte transversal en el que se estudió una muestra de 92 pacientes diabéticos seleccionados de forma aleatoria simple. Se realizó electrocardiograma, que cuando fue negativo para isquemia ameritó prueba de esfuerzo, o de lo contrario, ecocardiograma de estrés con dobutamina. Resultados: La edad media de los participantes fue de 57 años, 88% de los cuales eran mujeres; la duración media de la diabetes fue 7 años. Se encontró cardiopatía isquémica asintomática en el 22,8% de los casos. No se hallaron posibles asociaciones entre cardiopatía isquémica asintomática y edad, sexo, enfermedad arterial periférica, índice de masa corporal, índice tobillo-brazo, hipertensión arterial, dislipidemia, tabaquismo activo, sedentarismo, sobrepeso/obesidad, alcoholismo, glucosa en ayunas, hemoglobina glicosilada, colesterol total, colesterol HDL, colesterol LDL, ácido úrico, creatinina, tasa de filtrado glomerular y microalbuminuria. Conclusiones: La prevalencia de cardiopatía isquémica asintomática en la población estudiada con diabetes mellitus tipo 2 fue de 22,8%. No se encontraron posibles asociaciones de cardiopatía isquémica asintomática con las variables estudiadas.
Abstract Introduction: Cardiovascular disease is the main cause of death in patients with diabetes mellitus. The prevalence of asymptomatic ischaemic heart disease is higher in diabetic patients than in non-diabetic ones, and is associated with a worse prognosis. Objective: To determine the prevalence of asymptomatic ischaemic heart disease in patients with type 2 diabetes mellitus in a third level of care hospital in Guatemala, as well as to analyse the possible relationship of this disease with epidemiological, clinical, and metabolic characteristics. Methods: A cross-sectional study was conducted on a sample of 92 randomly selected diabetic patients. An electrocardiogram was performed, which when it was negative for ischaemia, an exercise stress test or a dobutamine stress echocardiogram was performed. Results: The mean age of the participants was 57 years, 88% of whom were women. The mean duration of the diabetes was 7 years. Asymptomatic ischaemic heart disease was found in 22.8% of case. No significant associations were found between ischaemic heart disease and age, gender, peripheral arterial disease, body mass index, ankle-brachial index, arterial hypertension, dyslipidaemia, active smoking, sedentarism, overweight/obesity, alcoholism, fasting glucose, glycosylated haemoglobin, total cholesterol, HDL-cholesterol, LDL-cholesterol, uric acid, creatinine, glomerular filtration rate, and urine microalbumin. Conclusions: The prevalence of asymptomatic ischaemic heart disease was 22.8% in the population studied with type 2 diabetes mellitus. No significant associations were found between ischaemic heart disease and the variables studied.
Subject(s)
Humans , Female , Middle Aged , Myocardial Ischemia , Diabetes Mellitus , Electrocardiography , Dobutamine , Exercise TestABSTRACT
La cardiotoxicidad por fármacos quimioterápicos es un efecto adverso frecuente y esperado. En este sentido se ha creado una especialización, la cardiooncología, que tiene como principal objetivo la prevención de estos efectos. La forma de expresión de este fenómeno es muy variada, pudiendo manifestarse como: insuficiencia cardíaca, hipertensión arterial, eventos coronarios agudos y/o trastornos del ritmo. La clave en la prevención está en la idividualización del riesgo cardiotóxico de cada paciente (en base a factores reconocidos como edad, sexo, irradiación mediastinal previa, tipo de fármaco, dosis acumulada, cardiopatía asociada previamente) y el riesgo potencial cardiotóxico de cada quimioterápico. En este sentido se han creado algoritmos de actuación fundamentados en la monitorización y el inicio de tratamiento precoz y oportuno de cada efecto, previniendo el mal mayor en cada paciente.
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Humans , Male , Female , Antineoplastic Agents/toxicity , Drug-Related Side Effects and Adverse Reactions , Cardiovascular Diseases/etiology , Alkylating Agents , Antibodies, Monoclonal , Antineoplastic Agents, Alkylating/adverse effects , Antineoplastic Agents, Alkylating/toxicity , Antineoplastic Agents/adverse effects , Anthracyclines/adverse effects , Anthracyclines/toxicity , Fluorouracil/adverse effects , Fluorouracil/toxicity , Protein Kinase Inhibitors , Toxoids/adverse effects , Toxoids/toxicityABSTRACT
Objective Study the expression of endothelin(ET) of ischaemic myocardium in rat. Method Sixty Wistar rats were randomly divided into 5 groups: coronary artery simply-ligated group,drug-pre-treated group(Isoproterenol,Pituitrin),coronary atherosclerotic group,sham-operated group(as control group). The samples were cut at 15min,30min,45min,60min,90min,120min after coronary (left anterior descending) ligation, and stained with HE and strept avidin-biotin enzyme complex(SABC)method. Results The expression of endothelin was observed with light microscope. Ischaemic myocardium showed ET-positive staining at the early stage of acute myocardial ischaemia in different groups and more in the pre-treated group. Conclusion the SABC-ET method may provide a new marker for diagnosing early myocardial ischaemia, which will be helpful in confirming the cause of sudden coronary death(SCD).
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The effect of endothelin (ET-1) on the function of the isolated perfused working guinea pig has been examined. ET- 1 wasshowed to exert a transient positive inotropic effect on the isolated heart, followed by a marked inhibition of cardiac function. Low dose of ET- 1(30,90 pmol?L-1) produced reversible inhibition. The effect of high dose of ET- 1 was irreversible, accompanied with increasing LDH significantly, indomethacin markedly augmented the vasoconstrictor and cardiac ischemia effects of ET-1. Our results suggest that the apparent inhibition of cardiac function on the isolatedperfused guinea pig heart after administration of ET-1 may be due to the effect of the myocardial ischaemia caused by progressive development of coronary vasoconstriction. In our experimental model, PGI2 has partially antagonizing effect on the vasoconstrictor action of ET-1.
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Jat(lOmg/kg iv) administered 5 min prior to ligation of left anterior descending coronary artery significantly decreased the incidence of arrhy-thmias(VT and VF)and mortality of rats during ischaemia and reper-fusion.It also delayed the onset and shortened the duration of arrhythmias. The size of myocardial infarction caused by coronary artery ligation was decreased by Jat ( 0.75mg/kg iv. 1 h before and 6 h after operation) in rabbits.
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0.05).②To be compared with the condition before balloon inflation,p wave dispersion during balloon inflation were significantly higher in the myocardial ischaemia groups(36.7?5.70 vs 46.3?4.21ms,36.9?4.59vs44.7?6.47ms,36.4?4.76vs44.8?5.88ms, P 0.05).Conclusion:The prolongation of p wave dispersion may be a marker for severe acute myocardial ischaemia.